Myeloperoxidase Targets Apolipoprotein A-I, the Major HDL Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions
نویسندگان
چکیده
Background: Oxidation of apolipoprotein A-I by myeloperoxidase has been proposed to deprive HDL of its cardioprotective effects. Result: Tyrosine 192 is the major site of chlorination in apoA-I in both plasma and lesion HDL isolated from humans. Conclusion: Chlorination of apolipoprotein A-I by myeloperoxidase generates a dysfunctional form of HDL in vivo. Significance: Quantifying apolipoprotein A-I chlorination might help diagnose and perhaps treat human cardiovascular disease.
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